GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311100/primaryOK200TranscriptomicsMus musculus OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311100GEOGSEfalseDecoding the Cell-Type and Spatial Roles of H19 in Cholestatic Liver Injury Through Single-Nucleus and Spatial TranscriptomicsDespite recent advances, Primary Sclerosing Cholangitis (PSC)-a chronic obstructive biliary disease-still lacks effective therapies to prevent disease progression or the need for liver transplantation. Long non-coding RNA H19 (H19) has been implicated in promoting PSC disease progression. However, the underlying cell-specific and molecular mechanisms by which H19 contributes to PSC pathogenesis remain incompletely understood. Here we used single nucleus RNA sequencing (snRNAseq) and spatial transcriptomics to elucidate the cell- and spatial-specific expression alterations associated with H19 in the Mdr2KO PSC mouse model.2026/04/30GSE311100GSM9316939GSM9316928GSM9316938GSM9316937GSM9316936GSM9316935GSM9316934GSM9316933GSM9316932GSM9316931GSM9316930GSM9316940GSM93169293017224247311100Mus musculus