GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311133/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311133GEOGSEfalseTranscriptome analysis of human coronary artery smooth muscle cells under pro-differentiation and pro-dedifferentiation treatmentsThis study explores the transcriptomic landscape of human coronary artery smooth muscle cells (HCASMCs) in response to stimuli that promote differentiation (Repsox) or dedifferentiation (PDGF-BB, IL-1b). Our RNA sequencing analysis identifies DNA damage-inducible transcript 4 (DDIT4) as a key regulator of vascular smooth muscle cell (VSMC) phenotypic switching, showing its significant upregulation in synthetic phenotypes and downregulation in contractile phenotypes. This dataset provides a resource for understanding the transcriptional programs governing VSMC plasticity in the context of vascular remodeling and atherosclerotic disease.2026/06/06GSE311133GSM9317519GSM9317529GSM9317518GSM9317517GSM9317528GSM9317516GSM9317527GSM9317515GSM9317526GSM9317525GSM9317524GSM9317523GSM9317522GSM9317521GSM931752023227311133Homo sapiens