{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311341/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311341"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"mRNA-seq profiles of HL-1 cardiomyocytes of Tachypacing and Non-tacypacing and with or without NAD+ and βOHB treatment","description":"We found that Tachypacing stimulation induced a metabolic shift from fatty acid oxidation (FAO) to glycolysis, along with mitochondrial dysfunction, oxidative stress, repressed mitophagy, and activated NLRP3 inflammation. Both NAD⁺ and βOHB significantly prevented mitochondrial and metabolic remodeling.","dates":{"publication":"2026/09/15"},"accession":"GSE311341","cross_references":{"GSM":["GSM9323739","GSM9323738","GSM9323744","GSM9323743","GSM9323742","GSM9323741","GSM9323726","GSM9323748","GSM9323747","GSM9323725","GSM9323746","GSM9323745","GSM9323740","GSM9323729","GSM9323728","GSM9323727","GSM9323749","GSM9323733","GSM9323732","GSM9323731","GSM9323752","GSM9323730","GSM9323737","GSM9323736","GSM9323735","GSM9323734","GSM9323751","GSM9323750"],"GPL":["28457"],"GSE":["311341"],"taxon":["Mus musculus"],"PMID":["[42647426]"]}}