{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311401/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311401"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Bulk RNA sequencing of CFF-16HBEge cells following plasmid lipofection or virus-like particle transduction","description":"Delivery strategies for gene editing applications can affect editing outcomes by eliciting distinct cellular responses. This work presents bulk RNA sequencing data from human bronchial epithelial CFF-16HBEge cells, following delivery of an adenine base editor and sgRNA as plasmid DNA via lipofection or as ribonucleoprotein complexes via engineered virus-like particles (eVLPs). Differential gene expression and gene ontology analyses revealed condition-specific transcriptional profiles. This dataset provides a resource for investigating cellular responses to gene editing delivery approaches in vitro.","dates":{"publication":"2026/07/01"},"accession":"GSE311401","cross_references":{"GSM":["GSM9324515","GSM9324516","GSM9324517","GSM9324518","GSM9324511","GSM9324512","GSM9324513","GSM9324514","GSM9324510"],"GPL":["34284"],"GSE":["311401"],"taxon":["Homo sapiens"]}}