GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311401/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311401GEOGSEfalseBulk RNA sequencing of CFF-16HBEge cells following plasmid lipofection or virus-like particle transductionDelivery strategies for gene editing applications can affect editing outcomes by eliciting distinct cellular responses. This work presents bulk RNA sequencing data from human bronchial epithelial CFF-16HBEge cells, following delivery of an adenine base editor and sgRNA as plasmid DNA via lipofection or as ribonucleoprotein complexes via engineered virus-like particles (eVLPs). Differential gene expression and gene ontology analyses revealed condition-specific transcriptional profiles. This dataset provides a resource for investigating cellular responses to gene editing delivery approaches in vitro.2026/07/01GSE311401GSM9324515GSM9324516GSM9324517GSM9324518GSM9324511GSM9324512GSM9324513GSM9324514GSM932451034284311401Homo sapiens