{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Tabular":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311487/suppl/GSE311487_17-CL1_shTENT5AB_master.polya.tsv.gz"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311487/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311487"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The TENT5A–ATXN2 axis modulates cellular survival during heat stress.","description":"Stress conditions elicit the formation of different kinds of stress granules. The assembly and composition of heat-induced stress granules remain poorly characterized. Here, we show that the cytoplasmic RNA polyadenylases TENT5A regulate the formation and function of ATXN2-positive heat-induced stress granules. Tent5a mRNA expression increases when somatic and germ cells are exposed to temperatures between 40°C and 42°C, but not upon exposure to other stressors. TENT5A decreases ATXN2 levels by reducing Atxn2 mRNA translation and accelerating ATXN2 protein decay. Upon heat exposure of the testis, ATXN2-positive stress granules are formed in pre-meiotic and meiotic cells independently of the presence of G3BP1 and the heat stress response protein DAZL. Depletion of TENT5A leads to increased cell-type-specific formation of ATXN2-positive stress granules and differentially regulates cell survival. In sum, TENT5A inhibits the formation of ATXN2-positive granules to modulate the heat shock response in vivo.","dates":{"publication":"2026/07/10"},"accession":"GSE311487","cross_references":{"GSM":["GSM9325936","GSM9325937"],"GPL":["24973"],"GSE":["311487"],"taxon":["Mus musculus"]}}