{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311511/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311511"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial and single-nucleus multi-omics profiling reveals heterogeneous endothelial cell overabundance in endocardial fibroelastosis","description":"Endocardial fibroelastosis (EFE) is a lethal fibrotic complication that affects up to 70% of patients with hypoplastic left heart syndrome (HLHS). The absence of effective therapies for EFE stems from a fundamental lack of understanding of its underlying cellular and molecular mechanisms. Progress in investigating EFE pathogenesis has been further constrained by the scarcity of patient-derived samples. Our study directly addresses this critical knowledge gap by performing an integrative multi-omics study—combining single-nucleus RNA/ATAC sequencing and high-resolution spatial transcriptomics (MERFISH) on human EFE and healthy heart tissues.","dates":{"publication":"2026/08/29"},"accession":"GSE311511","cross_references":{"GSM":["GSM9326209","GSM9326206","GSM9326205","GSM9326208","GSM9326207","GSM9326213","GSM9326202","GSM9326212","GSM9326201","GSM9326204","GSM9326203","GSM9326211","GSM9326200","GSM9326210"],"GPL":["24676"],"GSE":["311511"],"taxon":["Homo sapiens"]}}