{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311603/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311603"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a novel deeply quiescent neural stem cell population in the subventricular zone","description":"This study shows that a novel genetic tool, the Penk-CreAi9 line, expressing Cre recombinase under the Proenkephalin promoter and combined with the Ai9-tdTomato line, labels a distinct group of stem cells in the SVZ together with previously identified subgroups of B-cells and neuroblasts. Single-cell RNA sequencing (scRNA-seq) demonstrates that these cells represent a previously unappreciated population of qNSCs with a unique transcriptional profile and a less differentiated state than the canonically accepted GLAST+ NSCs. In particular, the analysis further reveals expression of 5-hydroxytryptamine receptor 2C (5-HT2C receptor) and prolactin receptor (PRLR), which were previously functionally correlated with qNSCs but not captured or profiled in RNAseq experiments. This study also identifies novel markers, including Kcnj13, a gene that encodes the potassium channel KiR7.1, that define the identity of these cells.","dates":{"publication":"2026/06/09"},"accession":"GSE311603","cross_references":{"GSM":["GSM9327973","GSM9327972","GSM9327975","GSM9327974"],"GPL":["21626"],"GSE":["311603"],"taxon":["Mus musculus"]}}