GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311655/primaryOK200GenomicsHomo sapiensNon-coding RNA profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311655GEOGSEfalseSperm sncRNA networks are synchronized by a coordination between adverse childhood experiences (ACE) and current stressReproductive fitness is impacted by sperm RNA composition, including that of small noncoding RNA (sncRNA). Our previous studies found that elevated perceived stress significantly altered dynamically expressed sncRNA and increased sperm motility. However, the lasting influence of stressors earlier in life, such as adverse childhood experiences (ACE), and its interaction with current stress on sperm sncRNA remain unclear. Therefore, in a longitudinal human cohort we examined differential sncRNA and co-expression networks associated with perceived stress and ACE. Utilizing computational modeling, we identified significant time-dependent interactions between ACE and perceived stress that altered both sncRNA levels and subtype coordination. Such changes across sncRNA are likely to significantly alter genes important for reproductive outcomes, reflecting a synchronized strategy by which current and past environments may impact the next generation. Evolutionarily, this specificity may preserve sncRNA modules essential for species survival while allowing refined changes in stress-responsive pathways for intergenerational fitness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 sapiens