{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311717/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":[" Sus scrofa","Macaca fascicularis"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311717"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Lipid-Associated Macrophage Polarization Drives Chronic Xenograft Fibrosis via APOE-SDC2 Signaling","description":"Chronic injury of xenografted kidneys, characterized by interstitial fibrosis and tubular atrophy, remains a critical barrier to clinical translation. We employed integrated single-nucleus RNA sequencing, spatial transcriptomics, and plasma proteomics on pig-to-cynomolgus monkey kidney xenografts. We identified lipid-associated macrophage polarization and macrophage-fibroblast crosstalk via APOE-SDC2 signaling as central mechanisms driving fibrosis. Combined immunosuppression suppressed this pathway and prevented injury progression.","dates":{"publication":"2026/05/01"},"accession":"GSE311717","cross_references":{"GSM":["GSM9330231","GSM9330198","GSM9330232","GSM9330199","GSM9330210","GSM9330211","GSM9330233","GSM9330234","GSM9330212","GSM9330235","GSM9330213","GSM9330214","GSM9330215","GSM9330216","GSM9330191","GSM9330192","GSM9330193","GSM9330194","GSM9330195","GSM9330196","GSM9330197","GSM9330230","GSM9330228","GSM9330206","GSM9330229","GSM9330207","GSM9330208","GSM9330209","GSM9330220","GSM9330221","GSM9330200","GSM9330222","GSM9330223","GSM9330201","GSM9330224","GSM9330202","GSM9330225","GSM9330226","GSM9330204","GSM9330205","GSM9330227","GSM9330217","GSM9330218","GSM9330219"],"GPL":["36361"],"GSE":["311717"],"taxon":[" Sus scrofa","Macaca fascicularis"]}}