GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311717/primaryOK200Transcriptomics Sus scrofaMacaca fascicularis OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311717GEOGSEfalseLipid-Associated Macrophage Polarization Drives Chronic Xenograft Fibrosis via APOE-SDC2 SignalingChronic injury of xenografted kidneys, characterized by interstitial fibrosis and tubular atrophy, remains a critical barrier to clinical translation. We employed integrated single-nucleus RNA sequencing, spatial transcriptomics, and plasma proteomics on pig-to-cynomolgus monkey kidney xenografts. We identified lipid-associated macrophage polarization and macrophage-fibroblast crosstalk via APOE-SDC2 signaling as central mechanisms driving fibrosis. Combined immunosuppression suppressed this pathway and prevented injury progression.2026/05/01GSE311717GSM9330231GSM9330198GSM9330232GSM9330199GSM9330210GSM9330211GSM9330233GSM9330234GSM9330212GSM9330235GSM9330213GSM9330214GSM9330215GSM9330216GSM9330191GSM9330192GSM9330193GSM9330194GSM9330195GSM9330196GSM9330197GSM9330230GSM9330228GSM9330206GSM9330229GSM9330207GSM9330208GSM9330209GSM9330220GSM9330221GSM9330200GSM9330222GSM9330223GSM9330201GSM9330224GSM9330202GSM9330225GSM9330226GSM9330204GSM9330205GSM9330227GSM9330217GSM9330218GSM933021936361311717 Sus scrofaMacaca fascicularis