{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311775/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311775"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"LL-37 inhibits EV71 infection by upregulating STAC","description":"LL-37, a 37-amino acid human-derived antimicrobial peptide, exhibits antiviral functions against multiple enveloped and non-enveloped viruses. We here report that the expression of the Stac is upregulated by LL-37 regardless of EV71 infection in Caco-2 colorectal adenocarcinoma cells. The treatment of LL-37 inhibits viral infection compared to the scramble(scr) control. In addition, LL-37 significantly upregulates the Stac expression in the presence or absence of EV71 infection, while the viral infection itself does not affect the expression of Stac. Take together, our data provide a novel mechanism of its antiviral activity for non-enveloped viruses, in which LL-37 modulates the host genes, interfering with the process of viral infection.","dates":{"publication":"2026/05/14"},"accession":"GSE311775","cross_references":{"GSM":["GSM9331893","GSM9331892","GSM9331895","GSM9331894","GSM9331897","GSM9331886","GSM9331896","GSM9331885","GSM9331899","GSM9331888","GSM9331887","GSM9331898","GSM9331891","GSM9331890","GSM9331901","GSM9331900","GSM9331889","GSM9331902"],"GPL":["24676"],"GSE":["311775"],"taxon":["Homo sapiens"],"PMID":["[42043231]"]}}