GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311775/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311775GEOGSEfalseLL-37 inhibits EV71 infection by upregulating STACLL-37, a 37-amino acid human-derived antimicrobial peptide, exhibits antiviral functions against multiple enveloped and non-enveloped viruses. We here report that the expression of the Stac is upregulated by LL-37 regardless of EV71 infection in Caco-2 colorectal adenocarcinoma cells. The treatment of LL-37 inhibits viral infection compared to the scramble(scr) control. In addition, LL-37 significantly upregulates the Stac expression in the presence or absence of EV71 infection, while the viral infection itself does not affect the expression of Stac. Take together, our data provide a novel mechanism of its antiviral activity for non-enveloped viruses, in which LL-37 modulates the host genes, interfering with the process of viral infection.2026/05/14GSE311775GSM9331893GSM9331892GSM9331895GSM9331894GSM9331897GSM9331886GSM9331896GSM9331885GSM9331899GSM9331888GSM9331887GSM9331898GSM9331891GSM9331890GSM9331901GSM9331889GSM9331900GSM933190224676311775Homo sapiens[42043231]