{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312068/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312068"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Deciphering HTLV-1-associated Lung Pathology: Inflammation, Monocyte Recruitment and Differentiation Triggered by HTLV-1-exposed Alveolar Epithelial Cells","description":"Individuals with Human T-Lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis are prone to pulmonary complications (e.g., bronchiectasis), linked to chronic inflammation. This study assessed the impact of HTLV-1 infection on lung inflammation by analyzing the alveolar transcriptome of A549 epithelial cells following exposure to HTLV-1. Co-culture with HTLV-1-infected MT-2 cells caused transcriptomic changes related to viral response, NF-kB activation, and inflammation. RT-qPCR confirmed elevated expression of the chemokine monocyte chemotactic protein-1 (MCP-1/CCL2) and CSF-1 in A549 MT-2 co-cultures. Increased CSF-1 expression was mechanistically linked to NF-kB signaling, using CRISPR/Cas9 RELA knockout. Supernatant from A549 MT-2 co-cultures triggered chemotaxis and macrophage differentiation of THP-1 and primary monocytes. STRING analysis revealed enrichment in pathways associated with monocyte infiltration and bronchiectasis, aligning with clinical and multi-ancestry GWAS data. Overall, this study highlights HTLV-1's role in driving inflammation and monocyte recruitment in the alveolar epithelium, potentially contributing to viral persistence and immune evasion.","dates":{"publication":"2026/06/10"},"accession":"GSE312068","cross_references":{"GSM":["GSM9337249","GSM9337244","GSM9337243","GSM9337242","GSM9337241","GSM9337248","GSM9337247","GSM9337246","GSM9337245","GSM9337240","GSM9337239","GSM9337238","GSM9337255","GSM9337233","GSM9337232","GSM9337254","GSM9337253","GSM9337231","GSM9337252","GSM9337230","GSM9337259","GSM9337237","GSM9337258","GSM9337236","GSM9337235","GSM9337257","GSM9337256","GSM9337234","GSM9337251","GSM9337250"],"GPL":["18573"],"GSE":["312068"],"taxon":["Homo sapiens"],"PMID":["[42026465]"]}}