GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312099/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312099GEOGSEfalseImmune cell sequencing after allogeneic hematopoietic cell transplantation [snATAC-seq]Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for hematologic malignancies. The primary non-relapse complication after allo-HSCT is graft-versus-host disease (GVHD). The use of T regulatory (Treg) cells to prevent GVHD has emerged as a promising allogeneic T cell immunotherapy in the form of Orca-T. However, the precise differences in immune states which may influence clinical outcomes after Orca-T compared with unmanipulated peripheral blood stem cell (PBSC) grafts remain unexplored. Using peripheral blood specimens longitudinally collected between 3 weeks and one year after leukemia treatment, we examined single-nucleus ATAC-seq and whole transcriptome sequencing (scRNA-seq) analysis of PBMC from 4 patients receiving either Orca-T or unmanipulated PBSC grafts and 2 mobilized donors.2026/05/27GSE312099GSM9337724GSM933772324676312099Homo sapiens[41758930]