{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312107/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312107"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"PerturbPair: A Dual-Modality Platform Integrating Perturb-seq and Optical Pooled Screening to Map Cellular Responses and Enable Cross-Modal Inference","description":"This dataset profiles transcriptional responses to genetic perturbations in primary bone marrow–derived macrophages (BMDMs) stimulated with lipopolysaccharide (LPS). Using a pooled CRISPR library targeting 1,030 genes (with ~4 sgRNAs per gene), we applied Perturb-seq to capture single-cell RNA sequencing (scRNA-seq) profiles at 9 hours post-LPS stimulation.","dates":{"publication":"2026/04/18"},"accession":"GSE312107","cross_references":{"GSM":["GSM9337846","GSM9337802","GSM9337801","GSM9337845","GSM9337844","GSM9337843","GSM9337806","GSM9337849","GSM9337805","GSM9337804","GSM9337848","GSM9337803","GSM9337847","GSM9337842","GSM9337841","GSM9337840","GSM9337835","GSM9337834","GSM9337833","GSM9337832","GSM9337839","GSM9337838","GSM9337837","GSM9337836","GSM9337870","GSM9337831","GSM9337830","GSM9337829","GSM9337824","GSM9337868","GSM9337823","GSM9337867","GSM9337866","GSM9337822","GSM9337821","GSM9337865","GSM9337828","GSM9337827","GSM9337826","GSM9337869","GSM9337825","GSM9337860","GSM9337820","GSM9337864","GSM9337863","GSM9337862","GSM9337861","GSM9337819","GSM9337818","GSM9337813","GSM9337857","GSM9337812","GSM9337856","GSM9337855","GSM9337811","GSM9337810","GSM9337854","GSM9337817","GSM9337816","GSM9337815","GSM9337859","GSM9337858","GSM9337814","GSM9337853","GSM9337852","GSM9337851","GSM9337850","GSM9337809","GSM9337808","GSM9337807"],"GPL":["13112"],"GSE":["312107"],"taxon":["Mus musculus"]}}