{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312184/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312184"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of HepG2 cells upon EZH2 knockdown","description":"This RNA-seq dataset was generated to investigate transcriptomic changes resulting from EZH2 knockdown in the human hepatocellular carcinoma cell line HepG2. Cells were treated with either control (untreated or si-NC) or si-EZH2. Differential gene expression analysis identified genes regulated by EZH2 depletion, enabling the characterization of EZH2-dependent transcriptional programs in HCC cells. This dataset provides a resource for studying the functional impact of EZH2 on hepatocellular carcinoma transcriptome and for validation of EZH2-targeted therapeutic strategies.","dates":{"publication":"2026/05/12"},"accession":"GSE312184","cross_references":{"GSM":["GSM9339944","GSM9339945","GSM9339946","GSM9339947","GSM9339940","GSM9339941","GSM9339942","GSM9339943"],"GPL":["24676"],"GSE":["312184"],"taxon":["Homo sapiens"],"PMID":["[41622630]"]}}