{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312606/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312606"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Enrichment of CD4-CD8- cytotoxic Vδ1/3 T cells in pulmonary tuberculosis disease","description":"Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of global morbidity and mortality. Although gamma-delta (γδ) T cells have increasingly been suggested to contribute to the TB immune response, quantitative and qualitative differences in this immune cell compartment between healthy and diseased individuals are not well-characterized. In this study, we used single-cell RNA sequencing to provide a high-resolution characterization of CD4-CD8- γδ T cells in peripheral blood across healthy Mtb-(non-)sensitized and TB disease pre-/post-treatment cohorts. We found an activated and cytotoxic gene signature in γδ T cells of TB disease compared to both healthy cohorts. Strikingly, these differences persisted through one year following TB disease diagnosis. These transcriptomic differences were largely mediated by an NK-like cytotoxic Vδ1 and Vδ3 subset that was enriched in TB disease. Our findings suggest long-lasting changes in the CD4-CD8- γδ T cell compartment and highlight specific subsets as potentially important in TB.","dates":{"publication":"2026/08/14"},"accession":"GSE312606","cross_references":{"GSM":["GSM9350002","GSM9350003","GSM9350004","GSM9350005","GSM9350000","GSM9350001","GSM9349978","GSM9349979","GSM9349998","GSM9349976","GSM9349999","GSM9349977","GSM9349992","GSM9349993","GSM9349990","GSM9349991","GSM9349996","GSM9349975","GSM9349997","GSM9349994","GSM9349995","GSM9349989","GSM9349987","GSM9349988","GSM9350006","GSM9350007","GSM9349981","GSM9349982","GSM9349980","GSM9349985","GSM9349986","GSM9349983","GSM9349984"],"GPL":["24676"],"GSE":["312606"],"taxon":["Homo sapiens"],"PMID":["[42662901]"]}}