{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312690/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312690"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Betulonic acid alleviates dexamethasone-induced MC3T3-E1 osteoblast injury: a transcriptomic sequencing analysis","description":"Steroid-induced osteonecrosis of the femoral head(SONFH) is a severe complication of glucocorticoid therapy, with oxidative stress playing a pivotal role in its pathogenesis. Betulonic acid (BA), a natural triterpenoid, exhibits antioxidant properties; however, its role in SONFH remains unclear. This study aimed to investigate the protective effect of BA against dexamethasone (DEX)-induced osteoblast injury and its underlying molecular mechanisms.Three experimental groups were established: control (NC), dexamethasone treatment group(DEX), and dexamethasone plus BA co-treatment group(DEX_BA), each with three biological replicates.","dates":{"publication":"2026/09/10"},"accession":"GSE312690","cross_references":{"GSM":["GSM9351502","GSM9351499","GSM9351498","GSM9351501","GSM9351500","GSM9351495","GSM9351494","GSM9351497","GSM9351496"],"GPL":["24247"],"GSE":["312690"],"taxon":["Mus musculus"],"PMID":["[42703376]"]}}