{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312823/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312823"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Colon cancer resistance to Integrated Stress Response (IRS) at a clonal level","description":"We explored a gene-editing approach to deplete ephrinB2 from colorectal cancer cell clones using a Doxycyline (Dox)-inducible lentiviral vector encoding a short hairpin (sh) RNA for ephrinB2 silencing via RNA interference. We discovered that shRNA-mediated gene silencing induced massive cell death in 596-7 cells (Ha T, et al. Antisense transcription from lentiviral gene targeting linked to an integrated stress response in colorectal cancer cells. Mol Ther Nucleic Acids. 2022;28:877-891.), with a small portion of cells maintaining viability.","dates":{"publication":"2026/04/06"},"accession":"GSE312823","cross_references":{"GSM":["GSM9354980","GSM9354978","GSM9354979","GSM9354976","GSM9354977","GSM9354975"],"GPL":["20301"],"GSE":["312823"],"taxon":["Homo sapiens"]}}