{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312900/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312900"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Tension-Induced Osteogenesis in periodontal ligament stem cells","description":"Orthodontic tooth movement (OTM) relies on alveolar bone remodeling governed by periodontal ligament stem cells (PDLSCs). The mechanotransduction pathways linking mechanical tension to osteogenesis remain unknown. PIEZO1 is a mechanosensitive cation channel that plays a pivotal role in cell function regulation and fate determination. In this study, PIEZO1 knockdown and RNA sequencing were performed to reveal the mechanism of tension-induced osteogenesis.","dates":{"publication":"2026/09/03"},"accession":"GSE312900","cross_references":{"GSM":["GSM9356641","GSM9356652","GSM9356640","GSM9356651","GSM9356650","GSM9356649","GSM9356648","GSM9356647","GSM9356646","GSM9356656","GSM9356645","GSM9356644","GSM9356655","GSM9356654","GSM9356643","GSM9356653","GSM9356642","GSM9356639"],"GPL":["24676"],"GSE":["312900"],"taxon":["Homo sapiens"]}}