{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313035/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313035"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"METIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatin","description":"This study aims to determine the efficacy, safety, and tolerability of the sequential addition of immune-modulating therapy to standard-of-care therapy of microsatellite-stable (MSS)/mismatch repair-proficient (pMMR) metastatic colorectal cancer (mCRC). Patients with MSS/pMMR-mCRC harbor tumor that can be transformed into an immunogenic disease by short-course oxaliplatin-based therapy, and may thereby benefit from the addition of immune-modulating therapy to improve outcome of the current oxaliplatin-based standard-of-care. Primary objective: To determine progression-free survival (PFS), in terms of failure of treatment strategy, of sequential treatment with the Nordic FLOX (5-Fluorouracil, oxaliplatin and leucovorin) regimen and nivolumab compared with the standard-of-care Nordic FLOX regimen in previously untreated MSS/pMMR-mCRC. Secondary objectives: To determine safety and tolerability of sequential treatment with the Nordic FLOX regimen and nivolumab compared with the standard-of-care Nordic FLOX regimen. To monitor and compare quality-of-life (QoL) alterations during therapy courses.","dates":{"publication":"2026/07/01"},"accession":"GSE313035","cross_references":{"GSM":["GSM9359436","GSM9359437","GSM9359438","GSM9359439","GSM9359472","GSM9359473","GSM9359474","GSM9359430","GSM9359431","GSM9359475","GSM9359432","GSM9359476","GSM9359477","GSM9359433","GSM9359434","GSM9359478","GSM9359435","GSM9359479","GSM9359470","GSM9359471","GSM9359447","GSM9359448","GSM9359449","GSM9359483","GSM9359440","GSM9359484","GSM9359485","GSM9359441","GSM9359486","GSM9359442","GSM9359443","GSM9359487","GSM9359488","GSM9359444","GSM9359445","GSM9359446","GSM9359480","GSM9359481","GSM9359482","GSM9359458","GSM9359459","GSM9359450","GSM9359451","GSM9359452","GSM9359453","GSM9359454","GSM9359455","GSM9359456","GSM9359457","GSM9359469","GSM9359425","GSM9359426","GSM9359427","GSM9359428","GSM9359429","GSM9359461","GSM9359462","GSM9359463","GSM9359464","GSM9359465","GSM9359466","GSM9359422","GSM9359423","GSM9359467","GSM9359424","GSM9359468","GSM9359460"],"GPL":["34295"],"GSE":["313035"],"taxon":["Homo sapiens"],"PMID":["[42322272]"]}}