GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313035/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313035GEOGSEfalseMETIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatinThis study aims to determine the efficacy, safety, and tolerability of the sequential addition of immune-modulating therapy to standard-of-care therapy of microsatellite-stable (MSS)/mismatch repair-proficient (pMMR) metastatic colorectal cancer (mCRC). Patients with MSS/pMMR-mCRC harbor tumor that can be transformed into an immunogenic disease by short-course oxaliplatin-based therapy, and may thereby benefit from the addition of immune-modulating therapy to improve outcome of the current oxaliplatin-based standard-of-care. Primary objective: To determine progression-free survival (PFS), in terms of failure of treatment strategy, of sequential treatment with the Nordic FLOX (5-Fluorouracil, oxaliplatin and leucovorin) regimen and nivolumab compared with the standard-of-care Nordic FLOX regimen in previously untreated MSS/pMMR-mCRC. Secondary objectives: To determine safety and tolerability of sequential treatment with the Nordic FLOX regimen and nivolumab compared with the standard-of-care Nordic FLOX regimen. To monitor and compare quality-of-life (QoL) alterations during therapy courses.2026/07/01GSE313035GSM9359436GSM9359437GSM9359438GSM9359439GSM9359472GSM9359473GSM9359474GSM9359430GSM9359431GSM9359475GSM9359432GSM9359476GSM9359477GSM9359433GSM9359434GSM9359478GSM9359435GSM9359479GSM9359470GSM9359471GSM9359447GSM9359448GSM9359449GSM9359483GSM9359440GSM9359484GSM9359485GSM9359441GSM9359486GSM9359442GSM9359443GSM9359487GSM9359488GSM9359444GSM9359445GSM9359446GSM9359480GSM9359481GSM9359482GSM9359458GSM9359459GSM9359450GSM9359451GSM9359452GSM9359453GSM9359454GSM9359455GSM9359456GSM9359457GSM9359469GSM9359425GSM9359426GSM9359427GSM9359428GSM9359429GSM9359461GSM9359462GSM9359463GSM9359464GSM9359465GSM9359466GSM9359422GSM9359423GSM9359467GSM9359424GSM9359468GSM935946034295313035Homo sapiens[42322272]