{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313127"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacological activation of UPR pathways and its impact on gene expression","description":"This study investigates how pharmacologic activationn of the PERK branch of the unfolded protein response (UPR) enhances the immunoregulatory function of FoxP3⁺ regulatory T cells (Tregs) in the context of intestinal inflammation. Using ER stress-inducing agents and PERK activators, combined with flow cytometry, bulk RNA sequencing, in vitro Treg conversion and suppression assays, ELISA, qRT-PCR, and immunoblotting, we demonstrate that PERK activation reduces gut inflammation and promotes Treg-mediated immune regulation. These findings identify the PERK pathway as a novel immunologic target for enhancing Treg function and mitigating chronic intestinal inflammation, offering translational relevance for therapeutic strategies in inflammatory bowel disease (IBD).","dates":{"publication":"2026/05/31"},"accession":"GSE313127","cross_references":{"GSM":["GSM9362383","GSM9362382","GSM9362387","GSM9362386","GSM9362385","GSM9362384"],"GPL":["34290"],"GSE":["313127"],"taxon":["Mus musculus"]}}