GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313191/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313191GEOGSEfalseEmbryonic quality control after implantation with lineage-specific elimination of aneuploid cellsAneuploidy is frequent in human pre-implantation embryos and a leading cause of early pregnancy loss, yet is rarely observed at birth, implying robust embryonic surveillance. Here we define how this surveillance operates after implantation using an integrated, three-lineage stem cell–derived embryo model that recapitulates the epiblast (EPI), visceral endoderm (VE), and extraembryonic ectoderm (ExE). Seeding of aneuploid cells into each lineage independently revealed lineage-specific fates: aneuploid cells were selectively depleted from EPI and VE but persisted within ExE. Live imaging captured their removal by apoptosis or physical extrusion. Single-cell RNA sequencing showed p53 activation and Myc repression in aneuploid cells, and pathway perturbations modulated their clearance, confirming causality. Together, these findings demonstrate a post-implantation, lineage-restricted quality-control program that eliminates aneuploid cells from the embryo proper while permitting extraembryonic tolerance. They also establish integrated embryo models as a tractable platform to dissect the molecular logic of developmental quality control.2026/05/21GSE313191GSM9363925GSM9363926GSM9363921GSM9363922GSM9363923GSM9363924GSM9363920GSM9363918GSM936391934290313191Mus musculus