GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313258/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313258GEOGSEfalseMetabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalatePhthalates are widely used as plasticizers and solvents in common consumer products and are suspected to be metabolism-disrupting chemicals (MDCs). Di-isononyl phthalate (DINP) is a commonly used phthalate, which has been shown to induce liver damage, but the mechanisms and human relevance remain unclear. The effects of DINP on hepatic lipid metabolism were studied using a diet-induced obesity model of C56BL/6J male mice. The mice were orally exposed to 0, 1.5, 15 or 150 mg/kg bw/d DINP for 20 weeks next to a high-fat diet (HFD) with 45% calories from fat (Research Diets D12451), followed by assessment of the liver transcriptome.2026/06/30GSE313258GSM9364746GSM9364747GSM9364748GSM9364749GSM9364790GSM9364791GSM9364753GSM9364754GSM9364755GSM9364756GSM9364750GSM9364751GSM9364752GSM9364739GSM9364779GSM9364738GSM9364780GSM9364781GSM9364742GSM9364786GSM9364787GSM9364743GSM9364744GSM9364788GSM9364745GSM9364789GSM9364782GSM9364783GSM9364784GSM9364740GSM9364741GSM9364785GSM9364768GSM9364769GSM9364770GSM9364775GSM9364776GSM9364777GSM9364778GSM9364771GSM9364772GSM9364773GSM9364774GSM9364757GSM9364758GSM9364759GSM9364764GSM9364765GSM9364766GSM9364767GSM9364760GSM9364761GSM9364762GSM936476334290313258Mus musculus