{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313263/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313263"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"MIZ-1 (c-Myc-interacting Zinc Finger Protein-1, ZBTB17) is required for efficient B cell receptor signaling [RNA-seq]","description":"B cell receptor (BCR) signaling is required for the regulation of normal B lymphocyte development. We found that mice expressing a POZ domain-deficient MIZ-1 (MIZ-1ΔPOZ) exhibit impaired BCR signaling. Transcriptomic and ChIP-seq analyses reveal that, in addition to autophagy related genes, MIZ-1 directly regulates genes involved in BCR signaling and actin cytoskeleton dynamics.","dates":{"publication":"2026/04/15"},"accession":"GSE313263","cross_references":{"GSM":["GSM9364900","GSM9364901","GSM9364902","GSM9364903"],"GPL":["13112"],"GSE":["313263"],"taxon":["Mus musculus"],"PMID":["[41972179]"]}}