{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313281/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Sus scrofa"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313281"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A single cell atlas of porcine hematopoietic development","description":"Domestic pigs are a globally important agricultural species that are increasingly used as large animal biomedical models to bridge the gap between rodents and non-human primates. A thorough understanding of the porcine immune system is needed to safeguard pig health through therapies and vaccines and better utilize swine as preclinical models. Here, we paired single-cell transcriptomic analyses with T and B cell receptor profiling to create a cell atlas of pig hematopoietic development using cells dissociated from central lymphoid organs during embryonic, neonatal, and adult life. We highlight the connection between fetal liver and bone marrow, B cell and gd T cell differentiation trajectories, granulopoiesis in fetal liver, and T and B cell receptor recombination kinetics. Our combined data provides new insights into pig immune system development and contributes a valuable resource for advancing pigs as a model to study blood and immune-related diseases in humans.","dates":{"publication":"2026/06/15"},"accession":"GSE313281","cross_references":{"GSM":["GSM9365219","GSM9365240","GSM9365221","GSM9365220","GSM9365227","GSM9365205","GSM9365204","GSM9365226","GSM9365207","GSM9365229","GSM9365228","GSM9365206","GSM9365223","GSM9365222","GSM9365225","GSM9365224","GSM9365209","GSM9365208","GSM9365230","GSM9365210","GSM9365232","GSM9365231","GSM9365238","GSM9365216","GSM9365215","GSM9365237","GSM9365218","GSM9365239","GSM9365217","GSM9365212","GSM9365234","GSM9365233","GSM9365211","GSM9365236","GSM9365214","GSM9365235","GSM9365213"],"GPL":["26351"],"GSE":["313281"],"taxon":["Sus scrofa"]}}