GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313281/primaryOK200TranscriptomicsSus scrofaExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313281GEOGSEfalseA single cell atlas of porcine hematopoietic developmentDomestic pigs are a globally important agricultural species that are increasingly used as large animal biomedical models to bridge the gap between rodents and non-human primates. A thorough understanding of the porcine immune system is needed to safeguard pig health through therapies and vaccines and better utilize swine as preclinical models. Here, we paired single-cell transcriptomic analyses with T and B cell receptor profiling to create a cell atlas of pig hematopoietic development using cells dissociated from central lymphoid organs during embryonic, neonatal, and adult life. We highlight the connection between fetal liver and bone marrow, B cell and gd T cell differentiation trajectories, granulopoiesis in fetal liver, and T and B cell receptor recombination kinetics. Our combined data provides new insights into pig immune system development and contributes a valuable resource for advancing pigs as a model to study blood and immune-related diseases in humans.2026/06/15GSE313281GSM9365219GSM9365240GSM9365221GSM9365220GSM9365227GSM9365205GSM9365204GSM9365226GSM9365207GSM9365229GSM9365228GSM9365206GSM9365223GSM9365222GSM9365225GSM9365224GSM9365209GSM9365208GSM9365230GSM9365210GSM9365232GSM9365231GSM9365238GSM9365216GSM9365215GSM9365237GSM9365218GSM9365239GSM9365217GSM9365212GSM9365234GSM9365233GSM9365211GSM9365236GSM9365214GSM9365235GSM936521326351313281Sus scrofa