{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313339/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313339"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic analysis of cancer-associated thrombosis in plasma EVs from patients with advanced lung adenocarcinoma.","description":"Venous thromboembolism (VTE) is a major contributor to morbidity and mortality in patients with advanced lung adenocarcinoma. Extracellular vesicles (EVs) are established mediators of the associated hypercoagulable state. We conducted a transcriptomic analysis of plasma EVs to identify molecular signatures specific to cancer-associated thrombosis (CAT) for refined risk stratification and therapeutic targeting. Methods: Plasma EVs from lung adenocarcinoma patients with (n=10) and without (n=11) VTE were analyzed by RNA-Sequencing. Differentially Expressed Genes (DEGs) were analyzed for pathway enrichment. Results: RNA-Seq identified 483 DEGs in VTE patients, with significant enrichment in pathways related to inflammation, neutrophil degranulation (NETs), and blood coagulation. Conclusion: Plasma EVs carry a potent, multi-cellular derived immuno-thrombotic mRNA signature that distinctly underlies CAT in lung adenocarcinoma.","dates":{"publication":"2026/06/18"},"accession":"GSE313339","cross_references":{"GSM":["GSM9366473","GSM9366484","GSM9366483","GSM9366472","GSM9366486","GSM9366475","GSM9366474","GSM9366485","GSM9366480","GSM9366471","GSM9366482","GSM9366470","GSM9366481","GSM9366469","GSM9366488","GSM9366477","GSM9366476","GSM9366487","GSM9366479","GSM9366489","GSM9366478"],"GPL":["30173"],"GSE":["313339"],"taxon":["Homo sapiens"]}}