GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313339/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313339GEOGSEfalseTranscriptomic analysis of cancer-associated thrombosis in plasma EVs from patients with advanced lung adenocarcinoma.Venous thromboembolism (VTE) is a major contributor to morbidity and mortality in patients with advanced lung adenocarcinoma. Extracellular vesicles (EVs) are established mediators of the associated hypercoagulable state. We conducted a transcriptomic analysis of plasma EVs to identify molecular signatures specific to cancer-associated thrombosis (CAT) for refined risk stratification and therapeutic targeting. Methods: Plasma EVs from lung adenocarcinoma patients with (n=10) and without (n=11) VTE were analyzed by RNA-Sequencing. Differentially Expressed Genes (DEGs) were analyzed for pathway enrichment. Results: RNA-Seq identified 483 DEGs in VTE patients, with significant enrichment in pathways related to inflammation, neutrophil degranulation (NETs), and blood coagulation. Conclusion: Plasma EVs carry a potent, multi-cellular derived immuno-thrombotic mRNA signature that distinctly underlies CAT in lung adenocarcinoma.2026/06/18GSE313339GSM9366473GSM9366484GSM9366483GSM9366472GSM9366486GSM9366475GSM9366474GSM9366485GSM9366480GSM9366471GSM9366482GSM9366470GSM9366481GSM9366469GSM9366488GSM9366477GSM9366476GSM9366487GSM9366479GSM9366489GSM936647830173313339Homo sapiens