{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313401/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Trichophyton interdigitale"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313401"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome analysis uncovers PacC-mediated metabolic adaptation in the dermatophyte pathogen Tricophyton interdigitale","description":"Purpose: We evaluated T. interdigitale H6 and PacC-1 mutant transcriptome using high-throughput RNA-sequencing (RNA-seq) technology aiming to identify metabolic pathways modulated by the transcription factor PacC. Methods: We employed the next-generation sequencing (RNA-seq) approach to identify the central genes related to PacC in response to keratin. Results: PacC acts as a central regulator of fungal adaptation and virulence in keratin-rich conditions, coordinating nutrient uptake, keratin degradation, and oxidative stress responses. Its mutation causes severe metabolic imbalance and cellular stress. Conclusions: Our findings provide insights into a specific molecular function of PacC in a infection-like medium, highlighting PacC-dependent pH adaptation pathways as potential therapeutic targets in dermatophytoses.","dates":{"publication":"2026/04/01"},"accession":"GSE313401","cross_references":{"GSM":["GSM9367441","GSM9367440","GSM9367443","GSM9367442","GSM9367438","GSM9367449","GSM9367448","GSM9367439","GSM9367445","GSM9367444","GSM9367447","GSM9367446"],"GPL":["36414"],"GSE":["313401"],"taxon":["Trichophyton interdigitale"],"PMID":["[41898497]"]}}