GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313401/primaryOK200TranscriptomicsTrichophyton interdigitaleExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313401GEOGSEfalseTranscriptome analysis uncovers PacC-mediated metabolic adaptation in the dermatophyte pathogen Tricophyton interdigitalePurpose: We evaluated T. interdigitale H6 and PacC-1 mutant transcriptome using high-throughput RNA-sequencing (RNA-seq) technology aiming to identify metabolic pathways modulated by the transcription factor PacC. Methods: We employed the next-generation sequencing (RNA-seq) approach to identify the central genes related to PacC in response to keratin. Results: PacC acts as a central regulator of fungal adaptation and virulence in keratin-rich conditions, coordinating nutrient uptake, keratin degradation, and oxidative stress responses. Its mutation causes severe metabolic imbalance and cellular stress. Conclusions: Our findings provide insights into a specific molecular function of PacC in a infection-like medium, highlighting PacC-dependent pH adaptation pathways as potential therapeutic targets in dermatophytoses.2026/04/01GSE313401GSM9367441GSM9367440GSM9367443GSM9367442GSM9367438GSM9367449GSM9367448GSM9367439GSM9367445GSM9367444GSM9367447GSM936744636414313401Trichophyton interdigitale[41898497]