{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313515/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313515"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulated Cholesterol Crystal-STING Pathway in Microglia Drives Neuroinflammation after Ischemic Stroke","description":"Dysregulated lipid metabolism is increasingly implicated in microglial activation, yet the specific consequences of massive cholesterol overload following permanent ischemia remain elusive. Using single-cell RNA sequencing in permanent distal middle cerebral artery occlusion (dMCAO) and perioperative ischemic stroke (PIS) models, we elucidated the pathogenic role of intracellular cholesterol crystals. We identified a progressive accumulation of cholesterol crystals within peri-infarct microglia during the subacute phase, driven by a specific downregulation of the lipid-processing enzyme lipoprotein lipase (LPL).","dates":{"publication":"2026/08/19"},"accession":"GSE313515","cross_references":{"GSM":["GSM9369471","GSM9369472"],"GPL":["28330"],"GSE":["313515"],"taxon":["Mus musculus"],"PMID":["[42578421]"]}}