{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313544/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313544"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Prime Editing Enables Isogenic Modeling of PNPLA3-I148M-Associated Lipotoxicity in Hepatocytes","description":"We demonstrate that prime editing enables a precise approach for modeling PNPLA3-I148M in human hepatocytes, offering a platform to investigate genotype-specific cellular responses. By combining precise genome editing with human cell modeling, this study provides new insight into the biology of a key risk allele and establishes a platform for personalized therapeutic strategies targeting genetically defined subgroups of liver disease.","dates":{"publication":"2026/07/01"},"accession":"GSE313544","cross_references":{"GSM":["GSM9369972","GSM9369973","GSM9369981","GSM9369970","GSM9369971","GSM9369982","GSM9369980","GSM9369969","GSM9369967","GSM9369978","GSM9369968","GSM9369979","GSM9369976","GSM9369977","GSM9369974","GSM9369975"],"GPL":["35417"],"GSE":["313544"],"taxon":["Homo sapiens"]}}