GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313544/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313544GEOGSEfalsePrime Editing Enables Isogenic Modeling of PNPLA3-I148M-Associated Lipotoxicity in HepatocytesWe demonstrate that prime editing enables a precise approach for modeling PNPLA3-I148M in human hepatocytes, offering a platform to investigate genotype-specific cellular responses. By combining precise genome editing with human cell modeling, this study provides new insight into the biology of a key risk allele and establishes a platform for personalized therapeutic strategies targeting genetically defined subgroups of liver disease.2026/07/01GSE313544GSM9369972GSM9369973GSM9369981GSM9369970GSM9369971GSM9369982GSM9369980GSM9369969GSM9369967GSM9369978GSM9369968GSM9369979GSM9369976GSM9369977GSM9369974GSM936997535417313544Homo sapiens