GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313587/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313587GEOGSEfalseBulk RNA Seq of Mouse RPE/Choroid from AAV-overexpressed IFN-beta and ControlType-I IFNs have been implicated in the development and progression of retinal disease, however the concequence of long term ocular exposure to Type-I IFN and the cell types that are impacted has not been characterized. This study uses AAV2 to overexpress IFN-beta to achieve prolonged retinal exposure with a single intravitreal injection. We have then employed a bulk RNA to examine the response of the RPE and choroidal cells to prolonged Type-I IFN exposure.2026/04/01GSE313587GSM9370653GSM9370654GSM9370655GSM9370656GSM9370649GSM9370650GSM9370651GSM937065224247313587Mus musculus[41760600]