{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313609/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313609"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Piezo1 Modulates Hematopoietic Homeostasis and Chronic Myelomonocytic Leukemia Progression","description":"We identified that PIEZO1 is crucial for maintaining hematopoietic homeostasis and is highly expressed in patients with chronic myelomonocytic leukemia (CMML), correlating with disease progression. To elucidate the underlying mechanism, we analyzed the gene expression profiles of c-Kit⁺ cells isolated from Nrasᴳ¹²ᴰ/ᴳ¹²ᴰ; Mx1-Cre CMML mice, CMML mice with conditional Piezo1 knockout, and control mice for comparative analysis. Our findings revealed that the cell adhesion pathway was one of the significantly enriched terms among the differentially expressed genes in Piezo1 conditional knockout (cKO) c-Kit⁺ cells, which was associated with altered expression of integrins.","dates":{"publication":"2026/06/12"},"accession":"GSE313609","cross_references":{"GSM":["GSM9370962","GSM9370963","GSM9370964","GSM9370965","GSM9370966","GSM9370967","GSM9370968","GSM9370969","GSM9370970"],"GPL":["24247"],"GSE":["313609"],"taxon":["Mus musculus"]}}