{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313629/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313629"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Melatonin modulates inflammasome and antioxidant signaling in trophoblasts and decidual macrophages","description":"This study investigates how melatonin regulates inflammatory and oxidative stress pathways at the maternal–fetal interface. We profiled transcriptomic responses in JEG-3 trophoblast-like cells and primary human decidual macrophages treated with melatonin at different doses. Cells were exposed to vehicle, 1 nM, or 1000 nM melatonin under defined inflammatory conditions. RNA-seq libraries were prepared using a strand-specific poly(A)-selected protocol and sequenced on a BGISEQ platform. Differential expression and pathway analyses focused on inflammasome and NRF2-related pathways. These data support a role for melatonin in modulating redox–inflammatory balance in placenta-relevant cell types.","dates":{"publication":"2026/06/03"},"accession":"GSE313629","cross_references":{"GSM":["GSM9371181","GSM9371180","GSM9371183","GSM9371182","GSM9371163","GSM9371185","GSM9371162","GSM9371184","GSM9371165","GSM9371187","GSM9371186","GSM9371164","GSM9371167","GSM9371189","GSM9371166","GSM9371188","GSM9371169","GSM9371168","GSM9371190","GSM9371170","GSM9371192","GSM9371191","GSM9371194","GSM9371172","GSM9371171","GSM9371193","GSM9371174","GSM9371196","GSM9371173","GSM9371195","GSM9371176","GSM9371197","GSM9371175","GSM9371178","GSM9371177","GSM9371179"],"GPL":["23227"],"GSE":["313629"],"taxon":["Homo sapiens"]}}