GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313725/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313725GEOGSEfalseHepatic multilineage organoids derived from hypoimmunogenic iPSCs for liver regenerative medicineHypoimmunogenic multicellular hepatic organoids were characterised by single-cell RNA sequencing to understand their cellular composition. Lineage cell identity was confirmed by gene and protein expression combined with ultrastructural analysis of cells by electron microscopy. Hepatic functional maturation was demonstrated by the production of liver-specific proteins, as shown by immunoassays. Together with the presence of a highly functional endothelial network, these properties confer therapeutic potential for inherited hepatic plasma protein deficiencies, end-stage liver disease and metabolic disorders.2026/03/26GSE313725GSM9373070GSM9373071GSM9373068GSM937306930173313725Homo sapiens