{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314094/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314094"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Pre-emptive Post-Reperfusion Cardioprotection with a Small Molecule in Rodents that Suppresses Genes Predictive of Heart Failure in Reperfused STEMI Patients","description":"We determined the post-reperfusion cardioprotective properties of BT2 in rat models of M/IR injury. Single nucleus RNA-seq of the AAR revealed that BT2 modulated the expression of key regulators of heart function, inflammation, extracellular matrix production and fibrosis, particularly in macrophages and myofibroblasts. Bulk RNA-seq showed BT2 downregulated multiple genes in the AAR associated with disease severity in ACS patients as well as genes predictive of HF in ST-elevation myocardial infarction (STEMI) patients undergoing PCI, including cytokines, inflammasome, damage-associated molecular patterns (DAMPs), DAMP-sensing receptors and biomarkers of HF.","dates":{"publication":"2026/05/20"},"accession":"GSE314094","cross_references":{"GSM":["GSM9381454","GSM9381453","GSM9381452","GSM9381461","GSM9381460","GSM9381459","GSM9381458","GSM9381457","GSM9381456","GSM9381455"],"GPL":["34877","20084"],"GSE":["314094"],"taxon":["Rattus norvegicus"],"PMID":["[42127187]"]}}