{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Tabular":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314181/suppl/GSE314181_abundance.kraken2.tsv.gz"],"Csv":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314181/suppl/GSE314181_methylation.comp.csv.gz"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314181/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314181"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Maternal trans-vaccenic acid reshapes neonatal T cell development and immune imprinting (LIME-seq)","description":"How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. Here, we report that maternal supplementation with 25 trans-vaccenic acid (TVA) – the predominant naturally occurring trans-fatty acid in human breast milk (HBM) – promotes neonatal T cell development in mice, particularly expanding the naïve CD4+ T cell population with enhanced readiness. This implements a shift from T helper (Th)2- biased neonatal immune responses to Th1-skewing, resulting in improved adaptive immunity against viral infection and lung inflammation. Mechanistically, TVA via breastfeeding reprograms neonatal naïve CD4+ 30 T cells through a G protein coupled receptor (GPR43)-CCCTC-binding factor axis for enhanced cooperation with transcription factor TBX21, which also exhibits a longlasting immune imprinting effect. Furthermore, TVA levels in HBM from mothers of preterm infants inversely correlate with the incidence of inflammation-associated bronchopulmonary dysplasia in their preterm infants. Our findings establish the multifaceted benefits of maternal 35 nutrition and breastfeeding via TVA in promoting infant immune homeostasis and protective immunity.","dates":{"publication":"2026/06/22"},"accession":"GSE314181","cross_references":{"GSM":["GSM9383512","GSM9383513","GSM9383514","GSM9383505","GSM9383506","GSM9383507","GSM9383508","GSM9383509","GSM9383510","GSM9383511"],"GPL":["34328"],"GSE":["314181"],"taxon":["Mus musculus"]}}