{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314201/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314201"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Activating transcription factor 6α governs stress-adaptive pancreatic β-cell mass expansion through the coordination of proliferation and survival","description":"We have employed a single cell RNA sequencing analysis using 10x Genomics scRNA-seq to investigate the role of ATF6α in pancreatic β-cells under chronic metabolic stress.ATF6α initiates a key branch of the unfolded protein response and has been implicated in β-cell survival, apoptosis, insulin secretory function, and glucose homeostasis. This study provides new insights into how ATF6α coordinate stress-adaptative transcriptional networks of β-cells leading to β-cell mass expansion under chronic metabolic stress, that contributes to the better understanding of preservation strategy of functional β-cell mass in diabetes.","dates":{"publication":"2026/07/01"},"accession":"GSE314201","cross_references":{"GSM":["GSM9384865","GSM9384861","GSM9384862","GSM9384863","GSM9384864"],"GPL":["24247"],"GSE":["314201"],"taxon":["Mus musculus"],"PMID":["[41996190]"]}}