GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314201/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314201GEOGSEfalseActivating transcription factor 6α governs stress-adaptive pancreatic β-cell mass expansion through the coordination of proliferation and survivalWe have employed a single cell RNA sequencing analysis using 10x Genomics scRNA-seq to investigate the role of ATF6α in pancreatic β-cells under chronic metabolic stress.ATF6α initiates a key branch of the unfolded protein response and has been implicated in β-cell survival, apoptosis, insulin secretory function, and glucose homeostasis. This study provides new insights into how ATF6α coordinate stress-adaptative transcriptional networks of β-cells leading to β-cell mass expansion under chronic metabolic stress, that contributes to the better understanding of preservation strategy of functional β-cell mass in diabetes.2026/07/01GSE314201GSM9384865GSM9384861GSM9384862GSM9384863GSM938486424247314201Mus musculus[41996190]