{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314414/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314414"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Temporal RNA-seq analysis of host transcriptional remodeling during lytic murine gammaherpesvirus 68 (MHV-68) infection","description":"Bulk RNA sequencing was performed to characterize host transcriptional changes during lytic murine gammaherpesvirus 68 (MHV-68) infection. NIH 3T3 cells were mock- or MHV-68-infected (multiplicity of infection of 5) and harvested at 4, 8, 12, and 24 hours post-infection, representing immediate early through very late stages of lytic replication. Differential expression analysis revealed extensive and time-dependent remodeling of host gene expression, including immune, metabolic, chromatin-associated, and transcriptional pathways. This dataset provides a temporal framework for understanding host responses during productive lytic gammaherpesvirus infection.","dates":{"publication":"2026/05/13"},"accession":"GSE314414","cross_references":{"GSM":["GSM9396009","GSM9396019","GSM9396008","GSM9396007","GSM9396018","GSM9396029","GSM9396028","GSM9396017","GSM9396027","GSM9396016","GSM9396015","GSM9396026","GSM9396025","GSM9396014","GSM9396024","GSM9396013","GSM9396012","GSM9396023","GSM9396022","GSM9396011","GSM9396010","GSM9396021","GSM9396020","GSM9396030"],"GPL":["30172"],"GSE":["314414"],"taxon":["Mus musculus"],"PMID":["[42198775]"]}}