GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314414/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314414GEOGSEfalseTemporal RNA-seq analysis of host transcriptional remodeling during lytic murine gammaherpesvirus 68 (MHV-68) infectionBulk RNA sequencing was performed to characterize host transcriptional changes during lytic murine gammaherpesvirus 68 (MHV-68) infection. NIH 3T3 cells were mock- or MHV-68-infected (multiplicity of infection of 5) and harvested at 4, 8, 12, and 24 hours post-infection, representing immediate early through very late stages of lytic replication. Differential expression analysis revealed extensive and time-dependent remodeling of host gene expression, including immune, metabolic, chromatin-associated, and transcriptional pathways. This dataset provides a temporal framework for understanding host responses during productive lytic gammaherpesvirus infection.2026/05/13GSE314414GSM9396009GSM9396019GSM9396008GSM9396007GSM9396018GSM9396029GSM9396028GSM9396017GSM9396027GSM9396016GSM9396015GSM9396026GSM9396025GSM9396014GSM9396024GSM9396013GSM9396012GSM9396023GSM9396022GSM9396011GSM9396010GSM9396021GSM9396020GSM939603030172314414Mus musculus[42198775]