{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314446/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":[" Mus musculus","Homo sapiens"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314446"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Human GPR15 deficiency reveals CD8+ T regulatory cell-macrophage crosstalk in intestinal inflammation","description":"We employed a CITE-seq combined with single-cell sequencing approach using 10x Genomics scRNA-seq to analyze peripheral and intestinal lymphocytes from Gpr15⁻/⁻ mice and from patients carrying deleterious GPR15 mutations. We show that GPR15, a G protein–coupled receptor (GPCR) expressed in immune cells and previously described as an entry co-factor for human and simian immunodeficiency viruses, serves as a crucial marker and homing receptor for a unique subset of intramucosal GPR15-guided regulatory CD8⁺ T lymphocytes (CD8⁺ TIGR cells). Our results demonstrate that deleterious GPR15 variants in humans impair the homing of CD8⁺ TIGR cells, leading to severe early-onset inflammatory bowel disease (IBD). In mice, GPR15 deficiency disrupts the colonic recruitment of CD8⁺ TIGR cells, causing an accumulation of inflammatory macrophages and heightened susceptibility to colitis. Together, our findings identify CD8⁺ TIGR cells as a previously unrecognized component of organ-specific immune regulation and reveal potential therapeutic avenues for the treatment of IBD.","dates":{"publication":"2026/05/05"},"accession":"GSE314446","cross_references":{"GSM":["GSM9396529","GSM9396528","GSM9396538","GSM9396527","GSM9396526","GSM9396537","GSM9396536","GSM9396525","GSM9396535","GSM9396524","GSM9396523","GSM9396534","GSM9396533","GSM9396532","GSM9396531","GSM9396530"],"GPL":["28330","34284"],"GSE":["314446"],"taxon":[" Mus musculus","Homo sapiens"]}}