{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314531/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314531"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"High-Resolution Spatial Transcriptomics of Irradiated Mouse Submandibular Gland Treated with Ep-FH","description":"Our previous studies developed a novel scaffold by chemically conjugating laminin-1 peptides (A99 and YIGSR) and growth factors, FGF-7 and FGF-10, to fibrin hydrogels (Ep-FH). The resulting hydrogel, Ep-FH applied via a single intraglandular injection to irradiated mouse submandibular gland (SMG), enhanced epithelial tissue organization while promoted secretory function after 60 days of treatment. Together these results suggest a remarkable potential for clinical applications; however, before applying Ep-FH in a clinical setting, it is necessary to understand how the treatment affects different cell populations within SMG. Therefore, the goal of this study was to perform high-resolution spatial transcriptomics (Xenium 10 Genomics) to characterize how treatment with Ep-FH alters irradiated mouse SMG cell populations as well as relevant signaling mechanisms.","dates":{"publication":"2026/08/23"},"accession":"GSE314531","cross_references":{"GSM":["GSM9401284","GSM9401283","GSM9401279","GSM9401278","GSM9401277","GSM9401276","GSM9401282","GSM9401281","GSM9401280"],"GPL":["33896"],"GSE":["314531"],"taxon":["Mus musculus"]}}