GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314531/primaryOK200OtherMus musculusOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314531GEOGSEfalseHigh-Resolution Spatial Transcriptomics of Irradiated Mouse Submandibular Gland Treated with Ep-FHOur previous studies developed a novel scaffold by chemically conjugating laminin-1 peptides (A99 and YIGSR) and growth factors, FGF-7 and FGF-10, to fibrin hydrogels (Ep-FH). The resulting hydrogel, Ep-FH applied via a single intraglandular injection to irradiated mouse submandibular gland (SMG), enhanced epithelial tissue organization while promoted secretory function after 60 days of treatment. Together these results suggest a remarkable potential for clinical applications; however, before applying Ep-FH in a clinical setting, it is necessary to understand how the treatment affects different cell populations within SMG. Therefore, the goal of this study was to perform high-resolution spatial transcriptomics (Xenium 10 Genomics) to characterize how treatment with Ep-FH alters irradiated mouse SMG cell populations as well as relevant signaling mechanisms.2026/08/23GSE314531GSM9401284GSM9401283GSM9401279GSM9401278GSM9401277GSM9401276GSM9401282GSM9401281GSM940128033896314531Mus musculus