GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314657/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314657GEOGSEfalseTwo translocation mechanisms drive neural stem cell dissemination into the human fetal cortexThe strong size increase of the human neocortex is supported by a neural stem cell population, the basal radial glial (bRG) cells. Using live imaging of human fetal tissue and cortical organoids, we identify two translocation mechanisms for bRG cell colonization of the human neocortex. On top of an actomyosin-dependent movement called mitotic somal translocation (MST), we identify a microtubule dependent motion occurring during interphase, that we call interphasic somal translocation (IST). We show that IST is driven by the dynein motor and its activator LIS1, that are recruited to the nuclear envelope by the LINC complex, while MST is controlled by the mitotic cell rounding pathway. 85% of bRG cell translocation is due to IST, for a total movement of 0,67 mm per month of gestation. Our work identifies how bRG cells colonize the human fetal cortex and further shows that IST and MST also occur in bRG-related glioblastoma cells.2026/06/21GSE314657GSM9407876GSM9407877GSM9407874GSM9407875GSM9407872GSM9407873GSM9407870GSM9407871GSM940786934281314657Homo sapiens[41844158]